Deprecated: Using ${var} in strings is deprecated, use {$var} instead in /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-content/plugins/sitepress-multilingual-cms/classes/API/REST/class-wpml-ate-proxy.php on line 128 Deprecated: Using ${var} in strings is deprecated, use {$var} instead in /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-content/plugins/sitepress-multilingual-cms/classes/API/REST/class-wpml-ate-proxy.php on line 128 Warning: Cannot modify header information - headers already sent by (output started at /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-content/plugins/sitepress-multilingual-cms/classes/API/REST/class-wpml-ate-proxy.php:128) in /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-includes/rest-api/class-wp-rest-server.php on line 1831 Warning: Cannot modify header information - headers already sent by (output started at /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-content/plugins/sitepress-multilingual-cms/classes/API/REST/class-wpml-ate-proxy.php:128) in /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-includes/rest-api/class-wp-rest-server.php on line 1831 Warning: Cannot modify header information - headers already sent by (output started at /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-content/plugins/sitepress-multilingual-cms/classes/API/REST/class-wpml-ate-proxy.php:128) in /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-includes/rest-api/class-wp-rest-server.php on line 1831 Warning: Cannot modify header information - headers already sent by (output started at /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-content/plugins/sitepress-multilingual-cms/classes/API/REST/class-wpml-ate-proxy.php:128) in /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-includes/rest-api/class-wp-rest-server.php on line 1831 Warning: Cannot modify header information - headers already sent by (output started at /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-content/plugins/sitepress-multilingual-cms/classes/API/REST/class-wpml-ate-proxy.php:128) in /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-includes/rest-api/class-wp-rest-server.php on line 1831 Warning: Cannot modify header information - headers already sent by (output started at /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-content/plugins/sitepress-multilingual-cms/classes/API/REST/class-wpml-ate-proxy.php:128) in /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-includes/rest-api/class-wp-rest-server.php on line 1831 Notice: file_get_contents(): Read of 12288 bytes failed with errno=21 Is a directory in /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-includes/functions.php on line 4623 Notice: Error when decoding a JSON file at path /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-content/themes/pi-pharmaimage-solutions/resources: Syntax error in /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-includes/functions.php on line 4626 Warning: Cannot modify header information - headers already sent by (output started at /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-content/plugins/sitepress-multilingual-cms/classes/API/REST/class-wpml-ate-proxy.php:128) in /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-includes/rest-api/class-wp-rest-server.php on line 1831 Warning: Cannot modify header information - headers already sent by (output started at /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-content/plugins/sitepress-multilingual-cms/classes/API/REST/class-wpml-ate-proxy.php:128) in /mnt/web507/d2/21/510769221/htdocs/pi/pi-pharmaimage/wp-includes/rest-api/class-wp-rest-server.php on line 1831 {"id":335,"date":"2021-09-27T16:14:16","date_gmt":"2021-09-27T14:14:16","guid":{"rendered":"http:\/\/dev.pi-pharmaimage.com\/?page_id=335"},"modified":"2021-11-12T15:18:26","modified_gmt":"2021-11-12T14:18:26","slug":"consulting","status":"publish","type":"page","link":"https:\/\/pi-pharmaimage.com\/consulting\/","title":{"rendered":"Consulting"},"content":{"rendered":"\n
Biomarkers<\/strong> are the bridge between basic and clinical research. It enables us to speed up the process of drug development (Winterer, G. The Handbook of Neuropsychiatric Biomarkers. Springer 2009). An NIH (National Institute of Health) study group committed to the following definition of biomarkers: A characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention (Biomarkers Definitions Working Group. Clin Pharmacol Ther 2001). This biomarker definition is relatively broad encompassing both physiological indicators (functional biomarkers) such as blood pressure, heart rate and brain function measures as well as molecular measures (molecular biomarkers) like gene expression, proteins, immunological markers etc.<\/p>\n\n\n\n Biomarkers are particularly useful when translating pre-clinical to clinical findings (bench-to-bedsite). Biomarkers can be helpful: <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n PI PharmaImage takes care of the required infrastructure for biomarker investigations wherever your patients or probands are located in Europe. This includes:<\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n Any valid biomarker study requires normative reference data for comparison. Reference data vary based on several factors, including the sociodemographic background of the healthy population from which imaging data or biological samples were obtained and the specific methods and\/or instruments used to collect the data\/samples. <\/p>\n\n\n\n Why is reference data important? <\/p>\n\n\n\n <\/p>\n\n\n\n In this regard, PI PharmaImage is in a worldwide unique position. Cross-sectional and longitudinal population-based normative reference data (3Tesla neuroimaging, electrophysiology, cognitive performance) and biological samples (blood, plasma) from > 4000 adult subjects across all age ranges with an emphasis on elderly subjects are available. The reference databank is continuously expanded. All data sets included undergo regular QC. Sociodemographic data are available for all subjects and all subjects have undergone extensive cognitive testing (mostly using the Cantab\u00ae test battery). Biomarker data can be combined with demographic and cognitive endpoints. Sample stratification can be conducted on the basis of predefined cut-offs for any imaging, electrophysiological or molecular measure as well as combination of measurements. Alternatively, using the normative reference post hoc evaluations may facilitate a better understanding of the obtained study results \u2013 positive or negative<\/p>\n<\/div>\n\n\n\n PI PharmaImage offers a wide range of in-house neuroimaging and electrophysiology capabilities. Generally, imaging and electrophysiological experiments are conducted close to the patients\/probands wherever they are (CROs, hospitals or at the patient\u00b4s home ). Imaging facilities are contracted on-site and\/or electrophysiological equipment is provided by PI PharmaImage for the duration of the study. PI PharmaImage also takes care of on-site staff training if required which includes regular monitoring. Data are transferred via cloud service and analyzed by PI PharmaImage staff in Berlin (Germany). Our imaging protocols are closely adapted to the protocols of ADNI (Alzheimer\u00b4s Disease Neuroimaging Initiative). Based on our population-based reference databank of electrophysiological and multimodal imaging data (cross-sectional, and longitudinal data from > 3000 healthy adult subjects across all age ranges which includes test-retest data), pre-selection (stratification) of study subjects (healthy, patients) can be conducted before volunteers\/patients enter the study (e.g. drug trial). Finally, study results including statistical analyses and reports are delivered to our customers.<\/p>\n<\/div>\n\n\n\n While the core competence of PI PharmaImage is in the field of neuroimaging and electrophysiology, we also support investigations with molecular biomarkers, in particular, we provide a large population-based reference database and take care of the required infrastructure (e.g. storage and transportation).<\/p>\n\n\n\n <\/p>\n\n\n\n PI PharmaImage provides support with fund raising to academic and private organizations being active in biomedical research. PI PharmaImage assists in finding an adequate strategy, building national and international consortia and delivering an administrative and management framework.<\/p>\n\n\n\n We offer over 20 years of expertise with successful fund raising and project management:<\/p>\n\n\n\n Major expertise with large national\/international biomedical research consortia (EU, DFG)<\/p>\n<\/div>\n\n\n\n Services are offered as modules. Whatever you need for your clinical study you can select from the following list:<\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n More information about our IT Infrastructure<\/p>\n<\/div>\n\n\n\nHow does it work?<\/h2>\n\n\n\n
Normative Reference Databank<\/h2>\n\n\n\n
Imaging & Electrophysiology Biomarkers<\/h2>\n\n\n\n
Molecular Biomarkers<\/h2>\n\n\n\n
International Fund Raising<\/h2>\n\n\n\n
Services offered by PI<\/h2>\n\n\n\n