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{"id":282,"date":"2021-09-27T14:42:00","date_gmt":"2021-09-27T12:42:00","guid":{"rendered":"http:\/\/dev.pi-pharmaimage.com\/?page_id=282"},"modified":"2021-11-15T17:13:55","modified_gmt":"2021-11-15T16:13:55","slug":"neuroimaging","status":"publish","type":"page","link":"https:\/\/pi-pharmaimage.com\/neuroimaging\/","title":{"rendered":"Neuroimaging"},"content":{"rendered":"\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile is-image-fill is-style-left\"><figure class=\"wp-block-media-text__media\" style=\"background-image:url(https:\/\/pi-pharmaimage.com\/wp-content\/uploads\/2021\/11\/fMRI-941x1024.jpg);background-position:50% 50%\"><img loading=\"lazy\" decoding=\"async\" width=\"941\" height=\"1024\" src=\"https:\/\/pi-pharmaimage.com\/wp-content\/uploads\/2021\/11\/fMRI-941x1024.jpg\" alt=\"\" class=\"wp-image-762 size-full\" srcset=\"https:\/\/pi-pharmaimage.com\/wp-content\/uploads\/2021\/11\/fMRI-941x1024.jpg 941w, https:\/\/pi-pharmaimage.com\/wp-content\/uploads\/2021\/11\/fMRI-276x300.jpg 276w, https:\/\/pi-pharmaimage.com\/wp-content\/uploads\/2021\/11\/fMRI-768x836.jpg 768w, https:\/\/pi-pharmaimage.com\/wp-content\/uploads\/2021\/11\/fMRI-1411x1536.jpg 1411w, https:\/\/pi-pharmaimage.com\/wp-content\/uploads\/2021\/11\/fMRI.jpg 1420w\" sizes=\"(max-width: 941px) 100vw, 941px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h2 class=\"wp-block-heading\">Neuroimaging experiments (fMRI, structural MRI)<\/h2>\n\n\n\n<p style=\"font-size:14px\"><strong>Neuroimaging experiments (fMRI, structural MRI)<\/strong> are conducted using MRI-scanners near the clinical study site. Scanner time is rented by PI PharmaImage on-site (in the proximity of the CRO or hospital where the clinical study is conducted), PI PharmaImage provides MR-sequences and staff (technical assistants\/physicians) are trained on-site if required. Imaging data analyses (e.g. event-related\/task-related, resting state fMRI, volumes of hippocampus or cholinergic nuclei) are conducted remotely in Berlin. Drug challenge imaging paradigms (ketamine\/nicotine) are also established. These paradigms allow testing of novel compounds whether they counteract or mimick the brain function resulting from the challenge drug. Simultaneous fMRI\/EEG experiments combining the sensitivity of EEG with spatial accuracy of MRI are possible, too. <\/p>\n\n\n\n<p style=\"font-size:14px\">Additional physiological measurements (ECG, skin conductance), tailored stimulation paradigms (e.g. cognitive, photic stimulation) can also be provided.<\/p>\n\n\n\n<p style=\"font-size:14px\"> All electrophysiological or neuroimaging data are transferred securely from the study site to Pharmaimage in Berlin where data analyses are conducted.<\/p>\n\n\n\n<p style=\"font-size:14px\">For more information see: <a href=\"https:\/\/pi-pharmaimage.com\/electrophysiology\/\" data-type=\"URL\">Imaging &amp; Electrophysiology Biomarkers<\/a><\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-columns is-style-background-and-borders is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<h2 class=\"wp-block-heading\">Hardware<\/h2>\n\n\n\n<p>The Pharmaimage hardware below can be delivered to the clinical study site (e.g. CRO):<\/p>\n\n\n\n<p>Simultaneous fMRI\/EEG investigations:<\/p>\n\n\n\n<ul><li> 1 complete MR-compatible EEG-recording BrainAmp MR Plus system (32 channels) with 2 recording dongles, 2 laptops, 4 BrainCaps MR, 2 syncboxes<\/li><\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\">Endpoints\/software standard packages:<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Imaging endpoints (fMRI):<\/p>\n\n\n\n<ul><li>Resting state, block design, event-related <\/li><li>ROI, whole-brain voxelwise <\/li><li>Functional connectivity analyses (seed-based, independent component analysis incl. default mode network analyses) <\/li><li>Additionally requested parameters or MR sequences (e.g. perfusion) are possible<\/li><\/ul>\n\n\n\n<p>Software: Statistical Parametric Mapping (SPM12)<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Imaging endpoints (structural MRI):<\/p>\n\n\n\n<ul><li>Sequences: MPRAGE, T2-SPACE, T2 (High-Res)<\/li><li> Whole-brain voxel-based morphometry, volume-based incl. subfield analyses (e.g. hippocampus, Ncl. Basalis Meynert), surface based analyses<\/li><\/ul>\n\n\n\n<p>Software: Freesurfer, DARTEL Toolbox<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Functional Magnetic Resonance Imaging<\/h2>\n\n\n\n<p>Functional magnetic resonance imaging (fMRI) is increasingly used in CNS drug research. As a functional biomarker, fMRI is frequently applied when it is the aim to detect local drug effects, particularly in subcortical circuits of the brain. <\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Perfusion imaging (Arterial Spin Labeling) also is of tremendous value, in particular to assess brain perfusion in elderly patients with (early) vascular dementia and to evaluated whether and how a particular drug affects brain perfusion. We offer: <\/p>\n\n\n\n<p><\/p>\n\n\n\n<ul><li>Study set-up and fMRI data acquisition incl. QC\/monitoring (and SOP for multicenter data acquisition).<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul><li>fMRI task conditions: resting (default mode network), N-back, verbal memory, oddball, reward etc.<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul><li>Data analysis: whole brain voxelwise, region-of-interest (ROI), seed-based functional connectivity and independent component analyses using the FSL\/SPM8 software packages<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul><li>Arterial Spin labeling (ASL): Pulsed ASL sequence with echoplanar readout and online calculation of CBF (cerebral blood flow) maps.<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul><li>Pharmaco-fMRI: established subanesthetic ketamine challenge, nicotine challenge<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul><li>Reference data from N = 100 clinically stable schizophrenia patients and &gt; N = 100 subjects with MCI (Mild Cognitive Impairment) are available (in addition to N = 1000 healthy control subjects).<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul><li>Special offer: Simultaneous fMRI\/EEG. e.g. for EEG-informed functional connectivity analyses without the need to define a priori an anatomical seed. For instance, EEG information (e.g. vigilance staging during the imaging session can be used for (partial) regression of the BOLD signal. Advantages: EEG together with fMRI increases sensitivity (e.g. to detect drug effects). EEG is a highly reliable measure, it stabilizes the obtained BOLD response measures (e.g. in default mode network analyses).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Structural Magnetic Resonance Imaging<\/h2>\n\n\n\n<p>In CNS drug research, structural MRI can be useful to define sub-groups of patients (e.g. dementia, MCI) or to monitor long-term (&gt; six months) drug effects.<\/p>\n\n\n\n<p>We offer:<\/p>\n\n\n\n<ul><li>Study set-up and MRI data acquisition incl. QC\/monitoring (and SOP for multicenter data acquisition).<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul><li>T2-weighted incl. high-resolution (e.g. hippocampus volume), T1-weighted, diffusion tensor imaging (DTI).<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul><li>Data analysis: VBM, ROI analyses including cholinergic nuclei (DARTEL Toolbox), fractional anisotropy, diffusivity, tractography, surface rendering using the Freesurfer software package or in-house software.<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul><li>Reference data from N = 100 clinically stable schizophrenia patients and &gt; N = 100 subjects with MCI (Mild Cognitive Impairment) are available (in addition to N = 1000 healthy control subjects).<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<ul><li>Upon request: Access to 7T ultrahigh-field MRI (e.g. for MR-imaging of blood-brain barrier, currently under development)<\/li><\/ul>\n\n\n\n<div class=\"wp-block-group is-style-background-border-right-top is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns is-style-frontpage is-layout-flex wp-container-core-columns-is-layout-3 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-text-color is-layout-flow wp-block-column-is-layout-flow\" style=\"color:#d80505\">\n<div style=\"height:43px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-black-color has-text-color\">More information about our IT Infrastructure<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\"><\/div>\n\n\n\n<button style=\"border:none;background-color:#1A5889;height:44px;width:200px;\"><a href=\"http:\/\/dev.pi-pharmaimage.com\/it-infrastructure\/\" style=\"color:#fff;text-decoration: none;\">IT INFRASTRUCTURE &gt;<\/a><\/button>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Hardware The Pharmaimage hardware below can be delivered to the clinical study site (e.g. CRO): Simultaneous fMRI\/EEG investigations: 1 complete MR-compatible EEG-recording BrainAmp MR Plus system (32 channels) with 2 recording dongles, 2 laptops, 4 BrainCaps MR, 2 syncboxes Endpoints\/software standard packages: Imaging endpoints (fMRI): Resting state, block design, event-related ROI, whole-brain voxelwise Functional connectivity &hellip; <a href=\"https:\/\/pi-pharmaimage.com\/neuroimaging\/\">Continued<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/pi-pharmaimage.com\/wp-json\/wp\/v2\/pages\/282"}],"collection":[{"href":"https:\/\/pi-pharmaimage.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pi-pharmaimage.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pi-pharmaimage.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pi-pharmaimage.com\/wp-json\/wp\/v2\/comments?post=282"}],"version-history":[{"count":43,"href":"https:\/\/pi-pharmaimage.com\/wp-json\/wp\/v2\/pages\/282\/revisions"}],"predecessor-version":[{"id":1326,"href":"https:\/\/pi-pharmaimage.com\/wp-json\/wp\/v2\/pages\/282\/revisions\/1326"}],"wp:attachment":[{"href":"https:\/\/pi-pharmaimage.com\/wp-json\/wp\/v2\/media?parent=282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}