Biomarker Solutions

Biomarkers

Content

Structural Magnetic Resonance Imaging

In CNS drug research, structural MRI can be useful to define sub-groups of patients (e.g. dementia, MCI) or to monitor long-term (> six months) drug effects.

Special offer: Quantifying volumes of cholinergic nuclei in the brain

MRI-Darstellung des Hirns
(A) The cholinergic NBM ( Ncl. Basalis Magnocellularis, formerly Meynert) viewed from anterior at the level of the anterior commissure. (B) displays the NBM at whole extent. The anterior-intermediate sector is coloured in blue, the posterior sector in yellow. DARTEL-based procedure implemented in SPM8 and a validated probabilistic map of the basal forebrain.
Lammers F, Mobascher A, Musso F, Shah NJ, Warbrick T, Zaborszky L, Winterer G (2016). Effects of Ncl. Basalis Meynert volume on the Trail-Making-Test are restricted to the left hemisphere. BRAIN AND BEHAVIOR. 6(1): DOI: 10.1002/brb3.421

We offer:

  • Study set-up and MRI data acquisition incl. QC/monitoring (and SOP for multicenter data acquisition)
  • T2-weighted incl. high-resolution (e.g. hippocampus volume), T1-weighted, diffusion tensor imaging (DTI)
  • Data analysis: VBM, ROI analyses including cholinergic nuclei (DARTEL Toolbox), fractional anisotropy, diffusivity, tractography, surface rendering using the Freesurfer software package or in-house software
  • Reference data from N = 100 clinically stable schizophrenia patients and > N = 100 subjects with MCI (Mild Cognitive Impairment) are available (in addition to N = 1000 healthy control subjects)
  • Upon request: Access to 7T ultrahigh-field MRI (e.g. for MR-imaging of blood-brain barrier, currently under development)

© PI-PharmaImage Germany GmbH 2017 | Webdesign: blickpunkt x, Köln

Cookies make it easier for us to provide you with our services. With the usage of our services you permit us to use cookies.
More information Ok Decline